Aims/Objectives
Primary Objectives
Secondary Objectives
Methods
Statistical Analysis
Baseline patient characteristics were summarised using standard descriptive statistics. Continuous variables were reported as means with standard deviation and categorical variables reported as number and percentages. All values excluded missing values.
Overall survival (OS), disease-free survival (DFS) and progression-free survival (PFS) were evaluated using the Kaplan-Meier method. Kaplan-Meier survival curves were constructed to estimate the median OS, DFS and PFS. Stratified survival curves were constructed using prespecified subgroups: age, sex, smoking status, Eastern Cooperative Oncology Group (ECOG) performance status and number of comorbidities. Comparison between the subgroups were performed using the log-rank test. Two-sided p values <0.05 were considered significant.
Statistical analyses were performed using R Version 4.0.3 (R Core Team, R Foundation for Statistical Computing, Vienna, Austria) and RStudio Version 1.4.1103 (RStudio, PBC, Boston, MA). Packages used for analysis included tidyverse, survival, survminer and gtsummary.
| Characteristic | N = 921 |
|---|---|
| Age (Years) | 80.0 (77.0, 83.0) |
| Age | |
| 75-80 | 49 (53%) |
| 81-85 | 32 (35%) |
| 86-90 | 11 (12%) |
| Sex | |
| Female | 42 (46%) |
| Male | 50 (54%) |
| Smoking Status | |
| Current | 4 (4.8%) |
| Never | 27 (32%) |
| Previous | 53 (63%) |
| ECOG Scale | |
| 0 | 25 (50%) |
| 1 | 23 (46%) |
| 2 | 2 (4.0%) |
| Number of Comorbidities | |
| 0 | 3 (3.3%) |
| 1 | 25 (27%) |
| 2 | 26 (28%) |
| 3 | 17 (18%) |
| 4 | 21 (23%) |
| Tumour Stream | |
| Breast | 6 (6.5%) |
| Colorectal | 16 (17%) |
| Cutaneous SCC | 1 (1.1%) |
| Gynaecology | 3 (3.3%) |
| Head and Neck | 3 (3.3%) |
| Lung | 28 (30%) |
| Melanoma | 8 (8.7%) |
| Merkel Cell | 1 (1.1%) |
| Neurological | 2 (2.2%) |
| Prostate | 4 (4.3%) |
| Sarcoma | 2 (2.2%) |
| Skin | 3 (3.3%) |
| Upper GI | 8 (8.7%) |
| Urogenital | 2 (2.2%) |
| Urological | 5 (5.4%) |
|
1
Median (IQR); n (%)
|
|
| Quantile | Months | 95% CI1 |
|---|---|---|
| 50% | 27.3 | 18.6, 45.7 |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 50% | 44.7 | 21.8, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 50% | 6.33 | 4.65, 10.4 |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 75-80, N = 49 | ||
| 50% | 36.8 | 26.4, - |
| 81-85, N = 30 | ||
| 50% | 12.0 | 7.71, - |
| 86-90, N = 11 | ||
| 50% | 25.4 | 12.0, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| Female, N = 41 | ||
| 50% | 27.3 | 12.0, 45.7 |
| Male, N = 49 | ||
| 50% | 28.6 | 17.9, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 0, N = 25 | ||
| 50% | 28.6 | 21.0, - |
| 1, N = 23 | ||
| 50% | 25.4 | 10.2, - |
| 2, N = 2 | ||
| 50% | 19.6 | 12.0, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| Current, N = 4 | ||
| 50% | 36.8 | 6.60, - |
| Never, N = 26 | ||
| 50% | 28.6 | 12.0, - |
| Previous, N = 52 | ||
| 50% | 26.4 | 18.6, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 0, N = 3 | ||
| 50% | 37.5 | 4.92, - |
| 1, N = 25 | ||
| 50% | 21.6 | 12.0, - |
| 2, N = 25 | ||
| 50% | 28.6 | 12.0, - |
| 3, N = 16 | ||
| 50% | 15.5 | 8.08, - |
| 4, N = 21 | ||
| 50% | 28.6 | 9.47, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 75-80, N = 21 | ||
| 50% | 56.4 | 23.6, - |
| 81-85, N = 8 | ||
| 50% | 5.42, - | |
| 86-90, N = 3 | ||
| 50% | 21.8 | 1.85, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| Female, N = 16 | ||
| 50% | 44.7 | 18.6, - |
| Male, N = 16 | ||
| 50% | 56.4 | 21.8, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 0, N = 7 | ||
| 50% | 11.7, - | |
| 1, N = 7 | ||
| 50% | 21.8 | 18.6, - |
| 2, N = 1 | ||
| 50% | 5.42 | |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| Current, N = 2 | ||
| 50% | 47.1 | 23.6, - |
| Never, N = 9 | ||
| 50% | 11.7, - | |
| Previous, N = 17 | ||
| 50% | 21.8, - | |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 1, N = 9 | ||
| 50% | 23.6 | 18.6, - |
| 2, N = 14 | ||
| 50% | 44.7 | 10.5, - |
| 3, N = 4 | ||
| 50% | 11.5, - | |
| 4, N = 5 | ||
| 50% | 56.4 | |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 75-80, N = 16 | ||
| 50% | 7.21 | 6.60, - |
| 81-85, N = 18 | ||
| 50% | 4.82 | 2.63, - |
| 86-90, N = 6 | ||
| 50% | 5.05 | 2.93, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| Female, N = 18 | ||
| 50% | 6.33 | 4.65, 19.8 |
| Male, N = 22 | ||
| 50% | 6.67 | 4.41, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 0, N = 7 | ||
| 50% | 6.60 | 2.43, - |
| 1, N = 10 | ||
| 50% | 5.63 | 2.63, - |
| 2, N = 1 | ||
| 50% | 25.2 | |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| Current, N = 1 | ||
| 50% | 3.67 | |
| Never, N = 15 | ||
| 50% | 6.33 | 4.82, - |
| Previous, N = 21 | ||
| 50% | 5.63 | 4.45, - |
|
1
CI = Confidence Interval
|
||
| Quantile | Months | 95% CI1 |
|---|---|---|
| 0, N = 3 | ||
| 50% | 25.5 | 1.62, - |
| 1, N = 12 | ||
| 50% | 5.04 | 2.63, - |
| 2, N = 9 | ||
| 50% | 5.59 | 2.93, - |
| 3, N = 8 | ||
| 50% | 7.04 | 6.33, - |
| 4, N = 8 | ||
| 50% | 6.60 | 4.65, - |
|
1
CI = Confidence Interval
|
||